Toxoid shown to be effective for the vaccination of healthy cattle, 3 months of age and older, against respiratory disease caused by M. haemolytica and disease caused by infectious bovine rhinotracheitis, bovine viral diarrhea virus (Type 1 and Type 2), bovine parainfluenza virus (PI3) and bovine respiratory syncytial virus (BRSV). A single dose has been shown to be effective against respiratory disease caused by M. haemolytica as early as 10 days after administration. Safety has been demonstrated in calves 28 days of age and older.